Inhibition of host cell translation elongation byLegionella pneumophilablocks the host cell unfolded protein response
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چکیده
منابع مشابه
Role of Oxidative Stress in Modulating Unfolded Protein Response Activity in Chronic Myeloid Leukemia Cell Line
Background: Recently, it has been revealed that tyrosine kinase inhibitors (TKIs) act through inducing both oxidative and endoplasmic reticulum (ER) stress in chronic myeloid leukemia cells. However, ER stress signaling triggers both apoptotic and survival processes within cells. Nevertheless, mechanisms by which TKIs avoid the pro-survival effects are not clear. The aim of this study was to ev...
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The intracellular pathogen, Legionella pneumophila, secretes ∼300 effector proteins to modulate the host environment. Given the intimate interaction between L. pneumophila and the endoplasmic reticulum, we investigated the role of the host unfolded protein response (UPR) during L. pneumophila infection. Interestingly, we show that the host identifies L. pneumophila infection as a form of endopl...
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What’s in your product? Come hear the latest advances in the field of biopharmaceutical HCP Testing ● Rare Reagents: Multiple Case Studies on how to develop your rare reagents, including selection of null cell lines, developing immunization strategies and assessing the specificity of your antibodies, characterization of antibodies and standards by 2-D Gels, western blots, and immunofractionation
متن کاملHost Cell Protein Workshop
What’s in your product? Come hear the latest advances in the field of biopharmaceutical HCP Testing ● Rare Reagents: Multiple Case Studies on how to develop your rare reagents, including selection of null cell lines, developing immunization strategies and assessing the specificity of your antibodies, characterization of antibodies and standards by 2-D Gels, western blots, and immunofractionation
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Besides its essential roles during development and homoeostasis of multicellular organisms, programmed cell death (i.e. apoptosis) plays a critical role in the regulation of host responses during infection with viruses, bacteria and parasites (Williams, 1994; Liles, 1997). Furthermore, modulation of apoptosis by microorganisms has now been widely recognized (Liles, 1997; Barry and McFadden, 199...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1508716112